Results of Other Medications on VIAGRA Sildenafil metabolism is principally mediated by CYP3A4 (main route) and CYP2C9 (minor route). For that reason, inhibitors of these isoenzymes may well lessen sildenafil clearance and inducers of such isoenzymes may enhance sildenafil clearance.Although sildenafil enhances some markers of disease in people wit

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